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A Multicenter, Randomized, Double Blind, Placebo Controlled Phase II Study of PL 14736 Enema in the Treatment of Mild-To-Moderate Ulcerative Colitis, Ulcerative Colitis Study Group

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doi: 10.3389/fendo.2023.1240279 Received 14 June 2023 Accepted 03 August 2023 Published 24 October 2023 Volume 14 - 2023 Edited by Ferdinando Carlo Sasso, University of Campania Luigi Vanvitelli, Italy Reviewed by Alfredo Caturano, University of Campania Luigi Vanvitelli, Italy

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This multifactorial approach resulted in the manifestation of typical clinical HFpEF features, including ventricular hypertrophy, increased collagen deposition and fibrosis, elevated blood pressure, and diastolic dysfunction