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Many individuals are seeking these drugs solely for weight loss purposes, despite not having a medical necessity for them

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Tirzepatide helps patients lose the largest amount of weight (15-21%) compared to most other medications in the weight loss category

Phase 2 data: 8.7 percent at 1 mg, 17.1 percent at 4 mg, 22.8 percent at 8 mg, and 24.2 percent at 12 mg over 48 weeks

Unlike GHRP-6 and hexarelin, which increase cortisol, prolactin, and appetite alongside GH release, ipamorelin is reported to produce GH release with minimal off-target hormonal effects, which is why it has become a preferred pharmacological tool for isolating GH-axis effects from cortisol and prolactin-related confounders in experimental design