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Lipid peroxidation is a free radical chain reaction, mediated by lipoxygenases such as arachidonate 15-lipoxygenase, which recognizes the double-bond sites of PUFAs in membrane phospholipids and converts them into lipid hydroperoxides [57, 61]

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Amylin lowers postprandial glucose through three combined actions: slowing gastric emptying, suppressing inappropriate postprandial glucagon (which reduces liver glucose output), and reducing food intake

Separate vials are better for staggered titration (start retatrutide alone first, then add cagrilintide at Week 9) and for users who have GI sensitivity

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