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Evidence synthesis: We integrate RCT evidence on weight and metabolic outcomes with exploratory findings on reproductive outcomes, highlighting key effect modifiers (baseline obesity/IR phenotype, concomitant metformin, and follow-up window)

Aetiological agents include tobacco, heavy alcohol consumption and the areca nut

Eligible subjects were randomised 1:1:1:1 to survodutide 2.4 mg ( N = 73), 4.8 mg ( N = 72), or 6 mg ( N = 74) once-weekly subcutaneously or to placebo ( N = 74) for 48 weeks

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Chaudhuri, A

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