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Hepatology 45 (5), 11641171

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The ALDH1 protein is a cytosolic enzyme while the ALDH2 proteins reside in the mitochondria

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Hallmark features of AD pathology include (I) age-dependent neurodegeneration that often manifests as gross neuroanatomical changes 12 - 14 , (II) the accumulation of pathological protein aggregates such as A plaques and neurofibrillary tangles (NFTs) 12 , (III) proliferation of glia (gliosis) and alterations in glial function that disrupt neuroimmune function and the blood brain barrier 12 , 15 , and (IV) an altered cellular landscape featuring multifaceted changes in cell signaling and metabolism, excessive oxidative stress, dysfunctional autophagy, impaired cell transport, and synaptic dysfunction 16 - 19