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And you look marvelous! When it comes to weight loss, how is all this working, without getting too scientific

injection of the experimental compound followed by measurements of tail vein blood glucose concentrations using a handheld glucometer (Contour XT, Bayers) at various timepoints over the following 24 hours

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Interestingly, even heterozygous Bbs5 +/ mice, which displayed normal body composition and energy metabolism compared with WT controls (Supplemental Figure 1, KV), were resistant to leptin (Supplemental Figure 3, K, L, O, and P), suggesting that leptin resistance may serve as a potential biomarker even in individuals with a single Bbs gene mutation

Once the plastic cap is off, sanitize the exposed stopper with alcohol and puncture through it as normal