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In its natural form, GLP-1 rises quickly after a meal, then vanishes within minutes, so it never makes it far enough to have a sustained therapeutic effect

52 , e13593 (2020)

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Short-acting agents (exenatide and lixisenatide) induce gastric emptying delay in a similar way to native GLP-1 and blunt postprandial glucose (PPG) excursions

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