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The inhibition of GSIS by lowering glucose levels was similar though between somatostatin knockout and wild-type mice

doi: 10.1002/jnr.23777 89

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Enzymatically-synthesized glycogen induces cecal glucagon-like peptide-1 production and suppresses food intake in mice

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The tirzepatide dose had been escalated from 7.5 mg to 10 mg in February 2023 and further increased to 12.5 mg on March 27, 2023, four days prior to the onset of acute abdominal pain