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The updated regulatory timeline: May 21, 2026: TRIUMPH-1 top-line data released June 2026: Detailed data presented at the 86th ADA Scientific Sessions Q4 2026: NDA submission to FDA (obesity indication) 2027: FDA review period (6-10 months standard

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Physiologically, GDF15 is expressed in many tissues at a low concentration, but increases in expression with tissue damage, cancer, metabolic diseases, CVD and inflammation