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Collectively, these findings suggest that disease-associated mutations, though mechanistically diverse, converge in their impact on astrocytic reactivity by resetting the threshold at which astrocytes enter reactive states

Mikkelsen K, Apostolopoulos V (2019) Vitamin B12, Folic Acid, and the Immune System

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In celiac disease trials, larazotide has been associated with less symptom exacerbation during gluten exposure, suggesting that tight junction modulation can have tangible clinical effects

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The single-cycle adenovirus replicates its genome (including the encoded spike transgene) 10,000 times but does not produce infectious virions