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This slow titration is often the safest way for someone with a sensitive gut to introduce a GLP-1 medication

Dosage GuidelinesAs directed by physician

Long-term persistent semaglutide users were less likely to require treatment intensification, and fewer users added new glucose-lowering treatments or initiated insulin compared with persistent DPP4i users

If a clinician is discussing alternatives, the relevant comparison is not just the sticker amount

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This low bioavailability reduces the chances of interaction with other medications which are being metabolized through the liver or kidneys