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The oxidized PRX dimer is reduced by TRX to complete the catalytic cycle

As the cells become weaker, they become more vulnerable to damage or apoptosis (cell death) from even small reductions in perfusion, which can occur if the individual becomes dehydrated or overheated, undergoes surgery, has a drop in blood pressure, engages is excess physical activity, has untreated sleep apnea, or experiences a traumatic shock

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Chronic Inflammation: Conditions that keep the immune system on "high alert" can deplete glutathione rapidly

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