Reviews have proposed that GLP-1 signaling, changes in adipose-derived stem cells, oxidative stress, and dermal remodeling could affect collagen support and skin architecture beyond the mechanical loss of facial fat
Scientific References 3 sources 1 Drucker DJ Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1 Cell Metabolism 27(4) 2018PMID: 29617641 PubMed 2 Wilding JPH, Batterham RL, Calanna S, et al
Important safety considerations for transdermal patches: Avoid applying external heat (such as heating pads, hot water bottles, electric blankets, or prolonged sun exposure) to the patch area, as this may increase drug absorption and side effects Do not cut patches or apply additional adhesives unless specifically instructed to do so Wash hands thoroughly after handling patches to avoid transferring medication to eyes or mucous membranes For patients currently using licensed injectable GLP-1 receptor agonists, continue to follow the administration instructions provided in the PIL and by your healthcare team
If you have Type 2 diabetes, cardiovascular disease, or sleep apnea alongside obesity, your provider should document those conditions prominently
Both contain semaglutide, a once-weekly injection
doi: 10.1007/s00394-022-02804-3
