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The questions that Phase 3 will need to answer and that regulators will scrutinize closely include cardiovascular outcomes over extended periods, liver function changes beyond the 48-week window, potential interactions with other metabolic agents, and safety in populations not well-represented in Phase 2
At lower doses, the margin is wider
At the practice of Dr
But losing weight is only part of the story, says Park
Most manufacturers recommend discontinuing the drug at least two months before a planned pregnancy because of the long elimination time of some agents
Injectable GLP-1 therapies have faced persistent challenges in real-world settings, including supply shortages, high monthly costs, and discontinuation rates linked to side effects and needle aversion
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