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While these advanced delivery systems have shown encouraging results in preclinical models (e.g., significantly increased intracerebral drug concentrations and more effective reduction of infarct volume), recent studies frequently lack standardized reporting of key pharmacokinetic parameters, hindering cross-study comparisons

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Medicine 102(23):e34027 Alourfi Z, Homsi H (2015) Precipitating factors, outcomes, and recurrence of diabetic ketoacidosis at a university hospital in Damascus

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