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The clinical use of TNF- itself as an anticancer drug is limited to local treatments due to its dose-limiting systemic toxicity

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Future research directions must prioritize three key directions: First, investigating the triggering factors of lactate-ferroptosis interactions across diverse biological contexts to enable the design of tissue-specific lactate-targeting therapeutic interventions

The risk outweighs the benefit in minor issues

As the body ages, circulating levels of this kda protein fragment decline sharply, which correlates with slower wound healing, reduced collagen production, and visible signs of skin aging