Tirzepatide and retatrutide are often grouped with GLP-1 medicines, but they activate more than the GLP-1 receptor
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Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with obesity
It is the most potent peptide for muscle growth but also carries more risk than the others in this section
The clinical trial evidence is now so strong (STEP, SURMOUNT, SELECT trials) that more payers are adding GLP-1 coverage
Anyone who develops unusual or concerning symptoms in particular tiredness, abdominal pain, itchy skin, dark urine, yellow eyes or skin and easy bruising after using these products should seek medical attention promptly