Buprenorphine Buprenorphine only partially activates the opioid receptor
Rarely, mild allergic reactions, temporary redness at the injection site, or light gastrointestinal upset may occur
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Buprenorphine, in contrast, is less limited in several countries
Buprenorphine was associated with a lower withdrawal score than 2 agonists (clonidine and lofexidine, seven studies in 902 patients), longer retention in treatment (five studies, 558 patients), and increased likelihood of withdrawal treatment completion (12 studies in 1,264 cases)
Fatigue: Some researchers report tiredness in early days of use