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The products only share one active ingredient, though, and Vertex said the combination of drugs used in Alyftrek has benefits over Trikafta, which generated sales of $8.9 billion in 2023

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Trulicity is an FDA-approved brand-name medication that is used as an adjunct to exercise and diet to improve glycemic control in adults with type 2 diabetes mellitus

Glucagon raises hepatic glucose output but also increases resting energy expenditure and lipolysis

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Second, considering the biological latency of GLP-1 RAs as well as the potential underdiagnosis of DR at baseline, we, therefore, undertook the analysis by excluding patients with less than 6 months of follow-up