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Those most at risk include vegans and vegetarians, people with digestive conditions such as Crohn's disease, coeliac disease or IBS, those taking long-term metformin or proton pump inhibitors, older adults whose ability to absorb B12 through the gut declines naturally with age, those with pernicious anaemia, and anyone with a history of chronic alcohol use

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Choline is essential for liver function, crucial for processing and eliminating fat

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This dual mechanism may enhance outcomes for GERD specifically compared to purely systemic delivery

Tirzepatide activates both of these receptor pathways simultaneously, which is why researchers and clinicians often describe it as a "twincretin." The appetite suppression effect is profound