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Elevated acetylcholine tone (from Semax) enhances GABAergic inhibition by increasing the synthesis of GABA itselfcholinergic neurons in the basal forebrain project to GABAergic interneurons, creating a feedback loop

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The first time we saw this was during the liraglutide trials where blood pressure reduction occurred within 2 weeks of initiation of therapy, which was before any meaningful weight benefit was demonstrated suggesting that weight loss is not the driver of the blood pressure benefits

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Right now, an incredible 74% of adults in the United states are overweight, including 43% who tip the scales into obesity