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JCI Insight (2020) 5:e140532

Common side effects include nausea, diarrhea, vomiting, constipation, and abdominal pain

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It can be postulated that not only taking hydrochlorothiazide but also taking ACE inhibitors seems to favor the development of non-melanoma skin cancer

The interaction profile, while not dangerous in most cases, requires professional oversight to manage effectively

Two factors compound: drug exposure scales with body weight (lighter body = more drug per pound), and physiological response varies by metabolic and cardiovascular phenotype