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Carbon dioxide (CO2) retention from opioid-induced respiratory depression can exacerbate the sedating effects of opioids

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This increases cellular sensitivity to growth hormone and downstream IGF-1 signaling, which drives collagen synthesis and extracellular matrix remodeling the biological foundation of tendon repair

The relatively large VIP values of -GluCys (2.26), LA (1.98), and D-lactate (1.70) showed that these metabolites were the main contributors to the patient-group separation in this study

In 2015, Obeid et al

Huntingford J.L., et al