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In the same time period, 66.1% of patients lost at least 10% of their body weight, while 47.9% lost at least 15%

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ncbi.nlm.nih.gov/pmc/articles/PMC7345585 U.S

3.2 Anti-obesogenic effects of nicotine were dependent on gut microbiota Nicotine has been reported to modulate the composition and metabolites of gut microbiota to reduce feeding and body weight (Ohue-Kitano et al., 2024)

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While these medications have relatively long half-lives, patients should be advised to take oral DMTs consistently with regard to meals and semaglutide dosing