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While brain interstitial fluid tau concentrations are reported to be nearly twice as high during the active period of the rest-activity cycle in humans [8], it is noteworthy that, to the best of our knowledge, no study has investigated whether the deletion of core clock genes, simulating circadian disruption, leads to an increase in tau hyperphosphorylation

They also inquire about any related symptoms such as nausea, vomiting, fever, changes in bowel or urinary habits, and menstrual history

People with eating disorders, binge-eating disorder (BED), or low intrinsic motivation may find behavioral-only programs less effective

Yao et al., 2009)

doi:10.1517/14656566.3.6.727 171