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Other relevant interactions: Colchicine (used for gout) may affect B12 absorption with long-term use Chloramphenicol (rarely used antibiotic) may blunt the haematological response to B12 treatment Monitoring considerations: Patients taking loop or thiazide diuretics require careful monitoring when initiating B12 therapy in severe deficiency, due to the risk of hypokalaemia during rapid cell production

The tradeoff is clear

Brief Explanation of D64.9 Healthcare providers normally append this code in the documentation when the patient suffers from anemia

Why is B12 difficult to absorb

In other words, the 1 in 10 people getting worse after starting with the B12 shots may just be the result of one of the other coexisting illnesses getting worse