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Permanent discontinuation of trial treatment due to AEs occurred in 6% to 7% of semaglutide patients and 3% to 4% of placebo patients in the STEP 1 to STEP 3 studies, and in 2% of semaglutide patients and 3% of placebo patients in the STEP 4 study, where patients had a 20-week run-in period (Table 36 and Table 37)

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