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In mice with KRAS-driven pancreatic ductal adenocarcinoma (PDAC), high iron diets and GPX4 depletion, which results in 8-OHG release, lead to macrophage infiltration and activation (Dai E

4C), suggesting that 32 23% of the internalized EV-derived-Rac1 were released to the cytosol under the assumption of the observation rate of the Halo tag to be 100% (Supplementary Fig