Because APAP-induced liver injury typically manifests with pericentral necrosis surrounded by senescent hepatocytes, the damage does not occur equally throughout liver lobules, but the damaged site is surrounded by undamaged hepatocytes
Cardiac fibroblasts promote ferroptosis in atrial fibrillation by secreting exo-miR-23a-3p targeting SLC7A11
demonstrated the strong translational potential of microengineered liver-on-chip platforms capable of reproducing species-specific hepatotoxic responses across rat, dog, and human models (212)
Damage in systemic lupus erythematosus and its association with corticosteroids
Tom M,Murdoch PDS,Durn RV
Further, these data suggest that at acute time points following Gclc genetic deletion, compensation by NRF1 could be responsible for the dispensable role of NRF2 in GSH-depleted conditions