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The medication protocol is not prescribed for those with a BMI under 30, active eating disorders, gallbladder disease, history of substance abuse, very recent bariatric surgery, pancreatitis, thyroid cancer, or other specific exclusions

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While its generally less common than other GI side effects, constipation may hang around longer and be more disruptive for some

The UK SmPC acknowledges that some patients may require a slower titration schedule or may need to remain at a lower maintenance dose of 1.7 mg if 2.4 mg is not tolerated

Cell Mol Life Sci 65:18361841