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In order to achieve the evidence of the oxidative background related to the outcome of specific symptoms and diseases, epidemiological studies can be encouraged, and the role of nutrition and targeted antioxidant therapy can be better defined

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Moreover, a randomized double-blind placebo-controlled clinical trial indicated that supplementation with Coenzyme Q10 (30 mg/day) and L-carnitine (500 mg/day) for 8 weeks had beneficial effects on migraine symptoms and serum levels of lactate (166)