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This dual function makes it an indispensable molecule for maintaining cellular integrity and function in the face of endogenous and exogenous stressors

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Tracking urinary symptoms over several years could reveal patterns not evident in shorter studies

Methods Study design The SEMPA trial (Effect of Empagliflozin and Semaglutide on Cardio-Renal Target Organ Damage in Patients with Type 2 Diabetes A Randomized Trial) was a 32 week investigator-initiated, randomised, partly placebo-controlled, partly open-label trial, designed to assess the separate and combined effects of semaglutide and empagliflozin on kidney oxygenation and arterial stiffness as two co-primary outcomes

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