Tau accumulation and its association with neurodegeneration and cognitive impairments demonstrated in the current study were reported in several previous animal 60,68,72 and in clinical studies, where total tau (t-tau) and p-tau have been recognized as essential biomarkers for AD and have undergone successful validation through controlled, large-scale, multicenter studies 80
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In contrast, transient interactions between the exendin-P5 N-terminus and TMD are clearly important for agonism, with the majority of residues within this cavity being required for eliciting cAMP signalling (Figures 4-5, Supplemental Figure 10)
