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It does not require any specific comorbidity, but Medicare still expects prior authorization documentation and pairing of the medication with structured nutrition and physical activity

Chronic stress elevates cortisol levels, which can promote fat storage, particularly visceral fat, and increase cravings for high-calorie comfort foods

Dec 2000;14(12):1567-79

[14] Later developments were done by M3 Biotechnology, a company founded to commercialize dihexa

14 A semaglutide and tirzepatide study in obese individuals yielded similar results, showing a reduction in alcohol intake, binge episodes, average drinks, and AUDIT scores