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The column was washed with acetonitrile for 10 min followed by a linear gradient back to the initial mixture of 30% acetonitrile with the flow rate 1 ml/min

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doi: 10.1016/j.pharmthera.2021.107992 10 ShaRXuYYuanCShengXWuZPengJet al

Copper is essential to human health as it is a component of many proteins, but hypercupremia (high copper level in the blood) can lead to copper toxicity if it persists and rises high enough