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Recent studies have shown that a high insulin demand causes some cells to go into a high-stress, low-insulin secretion phase (59)

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Thiazolidinediones (e.g., Pioglitazone, Rosiglitazone): Common side effects: Fluid retention, weight gain, increased risk of fractures

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Gastrointestinal Side Effects GLP-1 agonists often cause gastrointestinal side effects, such as nausea, vomiting, and diarrhea, especially when first starting the medication