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Bhatt HR, James VHT, Besser GM, Bottazzo GF, Keen H Nicolas JP, Gueant JL, Frmont S
Vitamin C in extremely high doses (more than 1000 mg taken with a b12 supplement) may reduce b12 absorption when taken together
For people with a genuine deficiency, yes, the evidence is solid
Key findings include a 70% increase in skin thickness after 12 days of topical application, wrinkle volume reduction of 55.8% and depth reduction of 32.8% in clinical studies, and accelerated wound healing across multiple models (Pickart et al., 2018)