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First, both used slow dose escalation specifically because the gastrointestinal effects are dose-related
Whether the addition of glucagon receptor agonism in retatrutide meaningfully alters the overall GI side effect burden compared with approved agents remains uncertain
Indirect Causes Shedding can stem from more than just the drug
But direct comparison reveals tirzepatide's substantial advantage, with clinical trial results showing approximately double the weight reduction achieved with Qsymia's most effective dosing regimen
That appears to be true in Phase 2
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