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Reducing glutathione production in lymphoma cells, either through pharmacological inhibition of glutamate cysteine ligase (GCL), the enzyme catalyzing the rate-limiting step in glutathione biosynthesis, or via knockdown of GCLC , the GCL catalytic subunit, sharply decreased cell growth in 3D gels and xenografts
Its a perfect storm, adding layers of complexity to the dealmaking process that in the past didnt exist
This is a decision to make together with your clinician based on your personal situation
When administered, it is endogenously divided into two amino acids in the body: alanine and glutamine
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