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The defect begins below the receptor When insulin binds to its receptor, it initiates a signalling sequence through the phosphoinositide 3-kinase/Akt/mTOR pathway (PI3K/Akt/mTOR), which governs glucose transporter type 4 (GLUT4) translocation the step that allows glucose to actually enter the cell

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To further investigate, data mining algorithms were applied for disproportionality analysis to quantitatively detect AE signals in the pharmacovigilance database