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While rarely severe enough to cause discontinuation, it is a hallmark of the triple agonist mechanism, likely linked to glucagons influence on sensory pathways or metabolic shifts in the peripheral nervous system
ESCC, Epidermal growth factor receptor
Furthermore, cellular antioxidant capability is also decreased by suppressed GPx4 expression (e.g., RSL3), which results in lipid peroxidation and ferroptosis [76]
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Semaglutide is a molecule that mimics a naturally occurring hormone