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Table 1 Summary of emerging therapeutic agents targeting ECM remodeling and associated pathways in metabolic MAFLD

Pharmacokinetic data revealed that the 200mg nimacimab monotherapy arm, which did not meet its primary endpoint, did not achieve the serum exposure predicted by preclinical models, warranting potential further study of nimacimab at higher doses

A suspected adverse event of another kind can also end it the labels direct discontinuation if pancreatitis is suspected and if a serious hypersensitivity reaction occurs

Karstens et al., 2019)