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The study indicates this may not be because the patients aren't producing enough glutathione, it may be because glutathione is being used at a higher rate in patients with type II diabetes

The behavioural and molecular effects last orders of magnitude longer

Unlike certain nutrients, such as fat-soluble vitamins or iron, which the body can store for extended periods, zinc lacks a dedicated storage system [29, 30]

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In mice and rats, three distinct GPx4 isoforms, cytosolic GPx4, mitochondrial GPx4 (mGPx4), and nuclear GPx4 (nGPx4), were identified with different functions