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Tirzepatide, as a dual GLP-1/GIP agonist, may have different gastric effects compared to pure GLP-1 agonists, though evidence remains limited [52]

Sitagliptin induces natriuresis by blocking distal tubular sodium reabsorptive mechanisms rather than proximal sodium uptake, which can be modulated by SGLT2 inhibitors

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J Intern.Med

GLP-1 receptor agonists have transformed the management of type 2 diabetes and obesity, but their mechanism of delaying gastric emptying presents important clinical considerations

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