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31 In brown and beige adipose depots, FGF21 stimulates thermogenesis and increases energy expenditure through activation of UCP1 and mitochondrial biogenesis

Heres what a U-shaped curve looks like (data points are invented for illustration purposes): Photo by Innerbody Research In this invented example, the intervention in question does its best job at reducing a negative biomarker at around 200mg, after which the effect tapers off and soon becomes almost nonexistent

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