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Regarding the serum GLP-1 and insulin levels, the levels of GLP-1 in T2DM and T2DM + sham group were significantly lower than NC group, compared with the T2DM + sham group, GLP-1 levels increased dramatically in T2DM + RYGB and T2DM + EX-4 groups (Figure 6H)

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doi: 10.3390/pharmaceutics15071816, 136

They can also be added into treatment regimens where previous treatment options have not worked

At the genomic level, Epitalon modulated the expression of key circadian rhythm genes: Clock expression in leukocytes decreased 1.8-fold, Cry2 expression doubled, and Csnk1e expression in lymphocytes decreased by 2.1-fold, all with statistical significance