In the case of lysosomal disorders, the disruption of autophagosome-lysosome fusion leads to a progressive accumulation of poly-ubiquitinated protein aggregates and dysfunctional mitochondria
Acyl-CoA synthetase long-chain family member 4 (ACSL4) preferentially activates polyunsaturated fatty acids such as arachidonic and adrenic acids, forming acyl-CoA derivatives that are incorporated into phosphatidylethanolamine (PE) by membrane-bound O-acyltransferases (MBOATs) [84,85]
Carnitine carries long-chain fatty acids into mitochondria to be oxidised for the creation of free energy and also takes the role of clearing metabolic waste from cells to assist energy metabolism
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BPC-157 for systemic healing signals, GHK-Cu for collagen remodeling and tissue remodeling at the surface level
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