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Bariatric surgery: Reduces absorptive surface area Bypasses sections of intestine Requires mandatory supplementation GLP-1 therapy: Preserves intestinal anatomy Does not bypass nutrient transporters Alters appetite rather than anatomy The mechanisms differ fundamentally

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This has enormous potential because the insulin resistance is what is causing the cardiovascular disease, DeFronzo said

Evidence tier: documented public record, primary sources throughout

Iron has been found to upregulate SLC7A11mRNA as a protective mechanism via increasing activities of the ROS-nuclear factor erythroid 2-related factor 2 (NRF2) signaling, which helps to inhibit ferroptosis in BMDM (79)