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Furthermore, NAMPT-mediated NAD + biosynthesis and sirtuins in the intestine are critical for intestinal homeostasis, including GLP-1 production [39]

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Acknowledgements The authors are thankful to the Riphah Institute of Pharmaceutical Sciences, Riphah International University and Department of Pharmacy, Iqra university Islamabad, for helping in this research work

In cryo-EM, flexibility and conformational heterogeneity present challenges during image processing