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Compared with EtOH-fed WT mice, KO mice were less susceptible to EtOH-induced deleterious effects, including body weight loss (reflected by less body weight gain), liver weight gain and hepatocyte damage (reflected by plasma ALT activity) (Table 1)

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Numerous studies have demonstrated that exercise promotes brain iron homeostasis and inhibits ferroptosis by regulating iron transport, antioxidant defenses, and lipid metabolism, thereby maintaining neural function and metabolic stability (Thirupathi et al., 2024)

Mortimer, 2022)

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